Manchester United kicked off their Europa League campaign poorly, losing 0-1 at home to Real Sociedad, while Arsenal's new signing Marquinhos scored in a 2-1 win at FC Zurich on Thursday.
Barcelona drew 1-1 at Valencia after Real Madrid lost 1-0 away to Alaves, allowing Sevilla to go top of La Liga with a 2-1 home win over Celta Vigo on Sunday. Here are five talking points from the weekend's La Liga action.
Cristiano Ronaldo scored his 400th goal for Real Madrid as Zinedine Zidane's side closed in on a first La Liga title since 2012, easing to a 4-1 win over Sevilla on Sunday while Neymar hit a hat-trick for Barcelona, who thrashed Las Palmas 4-1.
Barca, who were without injured talisman Lionel Messi, started on the back foot and fell behind when Nabil Fekir netted with a sublime angled strike in the 15th minute. Griezmann, who joined Barca last month from rivals Atletico Madrid, scored four minutes before halftime to level the scores.
Cesc Fabregas has returned to training as the Barcelona midfielder continues his recovery from a knee injury, the La Liga leaders said on Monday.
Barcelona trounced visitors Atletico Madrid 6-1 at the Nou Camp on Saturday to move into second place behind Villarreal in the Primera Liga. Villarreal have 16 points from six games after coming from behind to beat Real Betis 2-1 while Barca are on 13 after a scoring spree led by a double from Samuel Eto'o.
The Brazil striker pulled a hamstring towards the end of the previous campaign and has yet to feature in pre-season.
Thierry Henry said he will consider leaving Barcelona during the winter transfer window if coach Pep Guardiola leaves him on the bench too often.
All non-professional leagues have been cancelled although clubs in the top two divisions have resumed training in groups of up to 10 players.
The English champions will go through to the last 16 of the Champions League if they overcome Real Betis in Seville.
Hazard extra-time goal sends 10-man Real Madrid through to Copa del Rey final.
Barcelona earned a 1-1 draw with holders Sevilla in the first leg of the King's Cup last-16.
Eibar coach Jose Luis Mendilibar was also dismissed later for angry protests against referee Alejandro Hernandez Hernandez.
In the third-tier Europa Conference League, English Premier League club Leicester City will face Danish side Randers and Scottish club Celtic will take on Norwegian champions Bodo/Glimt in the knockout playoff round.
Both sides had already qualified for the knockout stage of the Champions League and all that was at stake was first or second place in the group.
Images from the matches played across football leagues in Europe on Sunday.
AC Milan scored a 4-0 win over Fenerbahce with Andrei Shevchenko scoring all four goals in their Champions League Group E victory.
Liverpool turn to the relative calm of their Champions League defence with a place in the last 16 at stake on Tuesday.
Morata, who had scored his first goal for the club in last week's 2-0 win over Villarreal, rose to head home from close range on the half-hour mark following a corner which had been flicked on by Atleti captain Diego Godin.
Manchester United beat Hungarian champions Debrecen 3-0 in the first leg of their third qualifying round tie on Tuesday.
Lionel Messi notched a 20th assist of the season to help a lacklustre Barcelona secure a 1-0 win away to Real Valladolid on Saturday, maintaining the pressure on La Liga leaders Real Madrid. Cristiano Ronaldo converted two penalties, both awarded for handballs and the second in the last minute, as Serie A leader Juventus twice hit back to draw 2-2 with Atalanta to move closer to a ninth successive Serie A title on Saturday.
Barcelona eased to a 3-0 win over Racing Santander to keep pace with leaders Sevilla in the Primera Liga.
Barcelona were in danger of being toppled from the top of La Liga standings on Sunday after they suffered a shock 2-1 defeat at Deportivo La Coruna.
The Brazilian playmaker returned from a two-game suspension at the weekend and scored twice in a 5-1 drubbing of Real Betis.
Rennes denied late Europa League equaliser due to little-known rule
Gareth Bale marked his return to action after a long injury layoff by sealing a 2-0 victory for Real Madrid over Espanyol on Saturday to provisionally stretch Zinedine Zidane's side's lead at the top of La Liga to three points.
Photos from the La Liga matches played on Sunday
Villarreal reclaimed fourth spot and a slim advantage in the race for a Champions League place with a 2-0 win at Malaga.
Atletico Madrid's faint hopes of chasing down runaway Liga leaders Barcelona suffered a fresh blow on Saturday as they were held to a 1-1 draw at home to Girona, meaning they could fall 11 points behind the Catalans by the end of the weekend.
Barcelona forward Ansu Fati will be sidelined for four months after undergoing knee surgery, the La Liga club said on Monday.
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Manchester City squandered a three-goal lead to draw 3-3 with Feyenoord in the Champions League on Tuesday.
Midfielder Dani Ceballos added: "It looks like us changing our coach worked. We have recovered some sensations we had lost and we have got the three points. Now our objective is to win all the games left and finish the season as well as possible."
Deportivo La Coruna have granted permission to Lucas Perez to withdraw from the squad to face Real Betis on Saturday amid media talks linking the striker to a potential move to Premier League club Arsenal.
